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Alendronic acid ( INN ) or alendronate sodium, sold in the U.S. under the trade name Fosamax among others, is a bisphosphonate drug used for osteoporosis, osteogenesis imperfecta, and several other bone diseases. It is marketed alone as well as in combination with vitamin D.
Merck’s U.S. patent on alendronate expired in 2008 and the drug is now available as a generic. It is the most widely prescribed bisphosphonate medicine in the United States.
1 Medical uses
3 Side effects
5.1 Mechanism of action
7 External links
Alendronic acid 35 mg (as alendronate sodium 45.7 mg) oral tablet
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Prophylaxis and treatment of female osteoporosis
Treatment of male osteoporosis
Prevention and treatment of corticosteroid-associated osteoporosis together with supplements of calcium and vitamin D
Treatment for Osteogenesis imperfecta in patients 18 years of age or older
Dental implants coating (experimental)
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Alendronate should not be used in:
Acute inflammations of the gastrointestinal tract (esophagitis, gastritis, ulcerations)
Clinically manifested osteomalacia
Certain malformations and malfunctions of the esophagus (strictures, achalasia)
Inability to stand, walk, or sit for 30 minutes after oral administration
Renal impairment or chronic kidney disease as evidenced by a creatinine clearance below 30ml/min
Hypersensitivity to alendronate or another ingredient in the product
Pregnancy and breastfeeding
Patients below 18 yrs. of age, as no clinical data exists for this population
Ulceration and possible rupture of the esophagus ; this may require hospitalization and intensive treatment. Gastric and duodenal ulceration may also occur.
Esophageal cancer, a meta-analysis concluded that bisphosphonate treatment is not significantly associated with excess risk of esophageal cancer.
General: infrequent cases of skin rash, rarely manifesting as Stevens–Johnson syndrome and toxic epidermal necrolysis, eye problems ( uveitis, scleritis ) and generalized muscle, joint, and bone pain (rarely severe) have been reported. In laboratory tests, decreased calcium and phosphate values may be seen but reflect expected action of the drug and are almost always not clinically relevant.
Osteonecrosis of the jaw (deterioration of the temporomandibular joint or TMJ) may occur while on this drug, if dental work of any kind is carried out.
Bone: alendronate has been linked in long-term users to the development of low-impact femoral fractures.
Food and drugs containing large amounts of calcium, magnesium or aluminium (antacids) decrease the absorption of alendronate. At least half an hour should pass after intake of alendronate before eating dairy products or taking the supplement or drug.
Highly active vitamin D analogues or fluorides: no data is available. Concomitant treatment should be avoided.
The additional beneficial effect of HRT (hormone replacement therapy) with estrogens / progestins or raloxifene in postmenopausal women with osteoporosis remains to be elucidated, but no interactions have been seen. The combination is therefore possible, but controversial.
Intravenous ranitidine increases the oral bioavailability of alendronate. No clinical consequences are known.
The combination of NSAIDs and alendronate may increase the risk of gastric ulcers. Both these drugs have the potential to irritate the upper gastro-intestinal mucosa.
Mechanism of action
Alendronate inhibits osteoclast -mediated bone-resorption. Like all bisphosphonates, it is chemically related to inorganic pyrophosphate, the endogenous regulator of bone turnover. But while pyrophosphate inhibits both osteoclastic bone resorption and the mineralization of the bone newly formed by osteoblasts, alendronate specifically inhibits bone resorption without any effect on mineralization at pharmacologically achievable doses. Its inhibition of bone-resorption is dose-dependent and approximately 1,000 times stronger than the equimolar effect of the first bisphosphonate drug, etidronate. Under therapy, normal bone tissue develops, and alendronate is deposited in the bone-matrix in a pharmacologically inactive form. For optimal action, enough calcium and vitamin D are needed in the body in order to promote normal bone development. Hypocalcemia should, therefore, be corrected before starting therapy.
Etidronate has the same disadvantage as pyrophosphate in inhibiting mineralization, but all of the potent N -containing bisphosphonates including Alendronate and also risedronate, ibandronate, and zoledronate, do not.
As with all potent bisphosphonates, the fraction of the drug that reaches the circulatory system intact (systemic bioavailability ) after oral dosing is low, averaging only 0.6–0.7% in women and in men under fasting conditions. Intake together with meals and beverages other than water further reduces the bioavailability. The absorbed drug rapidly partitions, with approximately 50% binding to the exposed bone surface; the remainder is excreted unchanged by the kidneys. Unlike with most drugs, the strong negative charge on the two phosphonate moieties limits oral bioavailability, and, in turn, the exposure to tissues other than bone is very low. After absorption in the bone, alendronate has an estimated terminal elimination half-life of 10 years.
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