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Gabapentin is a prescription drug, marketed as Neurontin and Horizant, that’s used to treat epilepsy.
Doctors can prescribe gabapentin to treat epilepsy in people older than 12, and partial seizures in children ages 3 to 12.
Gabapentin may also be prescribed to treat restless legs syndrome (RLS), to relieve numbness and tingling related to diabetes, to prevent hot flashes, and to relieve pain that can accompany shingles (known as postherpetic neuralgia ).
The Food and Drug Administration (FDA) approved gabapentin in 1993 under the brand name Neurontin for the drug manufacturer Pfizer.
In 2003, the FDA approved generic gabapentin, and it’s now made by several drug companies.
An extended-release form of gabapentin is available under the brand name Horizant.
In 2004, the drug maker Pfizer settled charges for marketing Neurontin for unapproved uses, and agreed to pay $430 million.
Other adverse effects are generally similar to those of opiates, although they are usually less severe, and can include respiratory depression, dysphoria and constipation. It has been shown that gabapentin presynaptically inhibits glutamate transmission and that gabapentin antagonizes AMPA-evoked responses in vivo.
Gabapentin had no effect on naproxen pharmacokinetic parameters. J Clin Psychiatry. 2001;62(6):474. 7. Ryback R, Ryback L. Gabapentin for behavioral dyscontrol. As a long time addict I can say with complete confidence that the abuse potential of gabapentin is almost non-existant, even when combined with other drugs.
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