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Mesalazine, also known as mesalamine or 5-aminosalicylic acid ( 5-ASA ), is an aminosalicylate anti-inflammatory drug
It is sold in an oral form to maintain remission in Crohn’s disease,
There are no data on use in pregnant women, but the drug does cross the placenta and is excreted in breast milk. The drug should not be used in children under two, people with kidney disease, or people who are allergic to aspirin.
Side effects are primarily gastrointestinal but may also include headache; GI effects include nausea, diarrhea and abdominal pain. There have been scattered reports of various problems when the oral form is used, including:problems caused by myelosuppression ( leukopenia, neutropenia, agranulocytosis, aplastic anaemia, and thrombocytopenia ), as well as hair loss, peripheral neuropathy, pancreatitis, liver problems, myocarditis and pericarditis, allergic and fibrotic lung reactions, lupus erythematosus -like reactions and rash (including urticaria ), drug fever, interstitial nephritis and nephrotic syndrome, usually reversible on withdrawal. Very rarely, use of mesalazine has been associated with an exacerbation of the symptoms of colitis, Stevens Johnson syndrome and erythema multiforme.
Mesalazine is the active moiety of sulfasalazine, which is metabolized to sulfapyridine and mesalazine.
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