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Sulfasalazine is a prescription medication used to treat the symptoms of ulcerative colitis including bowel inflammation, diarrhea (stool frequency), rectal bleeding, and abdominal pain. Sulfasalazine delayed-release (enteric-coated) is also used to treat rheumatoid arthritis in adults and children when other medications have not worked.
Sulfasalazine belongs to a group of drugs called aminosalicylates. It works by reducing inflammation (swelling) inside the body.
Sulfasalazine comes as regular and delayed-release tablets. It is usually taken four times daily after meals. Drink a full glass of water after taking sulfasalazine to protect the kidneys and to prevent kidney stones.
Common side effects include loss of appetite, nausea or vomiting, and headache.
Sulfasalazine is a prescription medication used:
​Sulfasalazine delayed-release is used to treat ulcerative colitis (as indicated above) as well as:
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Sulfasalazine may be found in some form under the following brand names:
Sulfasalazine is part of the drug class:
Serious side effects have been reported. See “Precautions”.
This is not a complete list of sulfasalazine side effects. Ask your doctor or pharmacist for more information.
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:
This is not a complete list of sulfasalazine drug interactions. Ask your doctor or pharmacist for more information.
This medication may make your skin more sensitive to sunlight. Avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. 
Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of sulfasalazine, there are no specific foods that you must exclude from your diet when receiving this medication.
Before receiving sulfasalazine tell your doctor about all of your medical conditions including:
Tell your doctor about all of the medications you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Tell your doctor if you are pregnant or plan to become pregnant.
The FDA categorizes medications based on safety for use during pregnancy. Five categories – A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.
Sulfasalazine falls into category B. There are no well-done studies that have been done in humans with sulfasalazine. In animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.
There have been case reports of neural tube defects (NTDs) in infants born to mothers who were exposed to sulfasalazine during pregnancy, but the role of sulfasalazine in these defects has not been established. However, oral sulfasalazine inhibits the absorption and metabolism of folic acid which may interfere with folic acid supplementation and diminish the effect of periconceptional folic acid supplementation that has been shown to decrease the risk of NTDs.
Tell your doctor if you are breastfeeding or plan to breastfeed.
Sulfasalazine has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from sulfasalazine, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.
If you take too much sulfasalazine call your local Poison Control center or seek emergency medical attention right away.

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