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Lansoprazole, sold under the brand name Prevacid among others, is a medication which inhibits the stomach ‘s production of gastric acid. There is no evidence that its effectiveness is different from that of other PPIs.
Lansoprazole is a proton-pump inhibitor (PPI) in the same pharmacologic class as omeprazole. Lansoprazole has been marketed for many years and is one of several PPIs available.
It is manufactured by a number of companies worldwide under several brand names. In the United States, it was first approved by the Food and Drug Administration (FDA) in 1995.
Contents
1 Medical uses
2 Side effects
3 Interactions
4 History
5 Society and culture
5.1 Patents
5.2 Availability
6 Research
7 References
8 External links
Medical uses
Lansoprazole is used for treatment of:
Ulcers of the stomach and duodenum, and NSAID -induced ulcers
Helicobacter pylori infection, alongside antibiotics (adjunctive treatment), treatment to kill H. pylori causing ulcers or other problems involves using two other drugs besides lansoprazole known as ” triple therapy “, and involves taking twice daily for 10 or 14 days lansoprazole, amoxicillin, and clarithromycin
Gastroesophageal reflux disease
Zollinger-Ellison syndrome
There is no good evidence that it works better than other PPIs.
Side effects
Side effects of PPIs in general may include:
Common: diarrhea, abdominal pain
Infrequent: dry mouth, insomnia, drowsiness, blurred vision, rash, pruritus
Rarely and very rarely: taste disturbance, liver dysfunction, peripheral oedema, hypersensitivity reactions (including bronchospasm, urinary, angioedema, anaphylaxis ), photosensitivity, fever, sweating, depression, interstitial nephritis, blood disorders (including leukopenia, leukocytosis, pancytopenia, thrombocytopenia ), arthralgia, myalgia, skin reactions Stevens–Johnson syndrome, toxic epidermal necrolysis, bullous eruption )
PPIs may be associated with a greater risk of hip fractures and Clostridium difficile -associated diarrhea. : 22
Interactions
Lansoprazole interacts with several other drugs, either due to its own nature or as a PPI.
PPIs reduce absorption of antifungals ( itraconazole and ketoconazole ) and possibly increase digoxin in plasma
Increases plasma concentrations of cilostazol (risk of toxicity)
Lansoprazole possibly interacts with, among other drugs:
sucralfate
ampicillin
bisacodyl
clopidogrel
delavirdine
fluvoxamine
iron salts
voriconazole
aminophylline and theophylline
astemizole
History
Main article: Discovery and development of proton pump inhibitors
Lansoprazole was originally synthesized at Takeda and was given the development name AG 1749.
Society and culture
Prevacid 30 mg
Patents
The lansoprazole molecule is off-patent and so generic drugs are available under many brand names in many countries;
Availability
Since 2009, lansoprazole has been available over the counter (OTC) in the U.S. in a marketed by Novartis as Prevacid 24HR. In Australia, it is marketed by Pfizer as Zoton.
Research
In vitro experiments have shown that lansoprazole binds to the pathogenic form of tau protein.
Lansoprazole is also a prodrug that targets the cytochrome bc1 complex of Mycobacterium tuberculosis once converted to lansoprazole sulfide in mycobacterial host cells.

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