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Mirtazapine is the generic form of the brand-name antidepressant Remeron, which is used to treat depression and other ailments.
In some patients, depression may be associated with abnormal levels of neurotransmitters, the brain chemicals that nerve cells use to communicate with each other.
Remeron (mirtazapine), which belongs to a class of drugs known as tetracyclic antidepressants, can treat depression by moderating the levels of neurotransmitters in the brain.
Antidepressants such as mirtazapine are also prescribed “off-label” to treat other conditions, such as post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and other anxiety disorders.
The drug has also been prescribed as an appetite stimulant.
(One of its most common side effects is weight gain.) Mirtazapine was approved by the Food and Drug Administration (FDA) for use as an antidepressant in 1996.
Its patent expired in 2004 and generic versions are now available.
Mirtazapine tablets have an elimination half-life of approximately 20 to 40 hours; therefore, dose changes should not be made at intervals of less than 1 to 2 weeks in order to allow sufficient time for evaluation of the therapeutic response to a given dose. Consequently, the prescriber should be aware that plasma mirtazapine levels may be increased in these patient groups, compared to levels observed in younger adults without renal or hepatic impairment (see PRECAUTIONS and CLINICAL PHARMACOLOGY). Based on these limited data, it is unknown whether or not the dose of mirtazapine tablets needed for maintenance treatment is identical to the dose needed to achieve an initial response.
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