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Imipramine
Imipramine is a prescription medication used to treat the symptoms of depression and to prevent bedwetting in children. This medication belongs to a group of drugs called tricyclic antidepressants (TCAs), which treat the symptoms of depression by adjusting the levels of natural chemicals in the brain. The exact way imipramine works to prevent bedwetting is unknown.
Imipramine comes in tablet and capsule forms and may be taken once or several times a day, depending on your doctor’s instructions. When imipramine tablets are used to prevent bedwetting in children, they are usually taken one hour before bedtime, or as one dose in the afternoon and another dose at bedtime.
Common side effects include nausea, weakness and dry mouth. Imipramine can cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how it affects you. 
CYP2D6 is a protein in your body that is involved in the elimination of imipramine and other drugs from your body. Some patients have less of this protein in their bodies, affecting how much of the drug gets eliminated. Levels of CYP2D6 can vary greatly between individuals, and those having less of this protein are known as “poor metabolizers.” 
CYP2D6 testing is done to determine whether you are a poor metabolizer. If you are a poor metabolizer, the levels of imipramine in your blood can become too high. As a result, you may be at an increased risk of having more side effects from imipramine. 
Your doctor may adjust your dose of imipramine if you are a poor metabolizer. 
Imipramine is a prescription medication used to treat depression and bedwetting in children.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Imipramine may be found in some form under the following brand names:
Imipramine is part of the drug class:
This is not a complete list of imipramine side effects. Ask your doctor or pharmacist for more information.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:
This is not a complete list of imipramine drug interactions. Ask your doctor or pharmacist for more information.
Serious side effects have been reported with imipramine including the following:
Imipramine can cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how imipramine affects you.
Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of imipramine, there are no specific foods that you must exclude from your diet when receiving this medication.
Before taking imipramine, tell your doctor about all of your medical conditions. Especially tell your doctor if you:
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Tell your doctor if you are pregnant or plan to become pregnant.
There are no well-controlled studies that have been done in pregnant women. However, there have been clinical reports of congenital malformations associated with the use of the drug. Imipramine should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.
Tell your doctor if you are breastfeeding or plan to breastfeed.
Limited data suggest that imipramine is likely to be excreted in human breast milk. Because of the possibility for adverse reactions in nursing infants from imipramine, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.
Take imipramine exactly as prescribed.
Imipramine comes in tablet and capsule forms and may be taken once or several times a day, depending on your doctor’s instructions.
When imipramine tablets are used to prevent bedwetting in children, they are usually taken one hour before bedtime, or as one dose in the afternoon and another dose at bedtime.
If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of imipramine at the same time.
Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.
The dose your doctor recommends may be based on the following:
The recommended dose range of imipramine for the treatment of depression is 75 mg-300 mg/day.
The recommended dose range of imipramine for the treatment of childhood enuresis is 25mg-50 mg/day in children under 12 years old.
The recommended dose range of imipramine for the treatment of childhood enuresis is 25mg-75 mg/day in children over 12 years old.
The recommended dose range of imipramine for the treatment of depression is 75 mg-300 mg/day.
If you take too much imipramine, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.
Suicidality and Antidepressant Drugs
Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of imipramine hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Imipramine hydrochloride is not approved for use in pediatric patients.

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